When Two Become One: The Limits of Causality Analysis of Brain Dynamics

Biological systems often consist of multiple interacting subsystems, the brain being a prominent example. To understand the functions of such systems it is important to analyze if and how the subsystems interact and to describe the effect of these interactions. In this work we investigate the extent to which the cause-and-effect framework is applicable to such interacting subsystems. We base our work on a standard notion of causal effects and define a new concept called natural causal effect. This new concept takes into account that when studying interactions in biological systems, one is often not interested in the effect of perturbations that alter the dynamics. The interest is instead in how the causal connections participate in the generation of the observed natural dynamics. We identify the constraints on the structure of the causal connections that determine the existence of natural causal effects. In particular, we show that the influence of the causal connections on the natural dynamics of the system often cannot be analyzed in terms of the causal effect of one subsystem on another. Only when the causing subsystem is autonomous with respect to the rest can this interpretation be made. We note that subsystems in the brain are often bidirectionally connected, which means that interactions rarely should be quantified in terms of cause-and-effect. We furthermore introduce a framework for how natural causal effects can be characterized when they exist. Our work also has important consequences for the interpretation of other approaches commonly applied to study causality in the brain. Specifically, we discuss how the notion of natural causal effects can be combined with Granger causality and Dynamic Causal Modeling (DCM). Our results are generic and the concept of natural causal effects is relevant in all areas where the effects of interactions between subsystems are of interest

From Synchrony to Harmony: Ideas on the Function of Neural Assemblies and on the Interpretation of Neural Synchrony

Point of departure are experimental data acquired by simultaneous recording of the activity of a number (2–16) of individual neurons during presentation of a sensory stimulus. The area under investigation is the auditory midbrain (Torus semicircularis) of the immobilized grassfrog (Rana temporaria L.). The sensory stimuli are both artificial (noise, tones and clicks) and natural sounds (vocalizations and environmental sounds). The goal of investigation is an insight into the neural representation of the sensory environment

Scale-space theory for auditory signals

We show how the axiomatic structure of scale-space theory can be applied to the auditory domain and be used for deriving idealized models of auditory receptive fields via scale-space principles. For defining a time-frequency transformation of a purely temporal signal, it is shown that the scale-space framework allows for a new way of deriving the Gabor and Gammatone filters as well as a novel family of generalized Gammatone filters with additional degrees of freedom to obtain different trade-offs between the spectral selectivity and the temporal delay of time-causal window functions. Applied to the definition of a second layer of receptive fields from the spectrogram, it is shown that the scale-space framework leads to two canonical families of spectro-temporal receptive fields, using a combination of Gaussian filters over the logspectral domain with either Gaussian filters or a cascade of first-order integrators over the temporal domain. These spectro-temporal receptive fields can be either separable over the time-frequency domain or be adapted to local glissando transformations that represent variations in logarithmic frequencies over time. Such idealized models of auditory receptive fields respect auditory invariances, can be used for computing basic auditory features for audio processing and lead to predictions about auditory receptive fields with good qualitative similarity to biological receptive fields in the inferior colliculus (ICC) and the primary auditory cortex (A1).QC 20150407</p